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In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-α, IL-1β, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects (Tian et al., 2015)
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Infertility Correct cell division during spermatogenesis and oogenesis requires THF for dTMP synthesis [139], while genomic imprinting depends on SAM and DNA methyltransferases (DNMTs) to create a parent-specific DNA methylation pattern [140]
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