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the level of OCT1 protein was time-dependently increased in the ipsilateral L4/5 DRGs of rats after CCI of the sciatic nerve, which is responsible for the upregulation of Dnmt3a mRNA and protein and the downregulation of Oprm1 mRNA and MOR protein triggered by DNMT3a , to promote the development of NP [116]
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Evidence indicates that these compounds exert protective effects through activation of endogenous antioxidant systems, modulation of inflammatory pathways, enhancement of neurotrophic factors, and protection of mitochondrial function
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