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Absorption and retention Classic tracer studies found that at physiological oral doses (roughly 1–25 micrograms), cyanocobalamin, hydroxocobalamin, methylcobalamin, and adenosylcobalamin are absorbed at broadly similar fractional rates, with the absorbed fraction falling sharply as dose rises — from roughly half at 1 microgram to under 10% at 25 micrograms, reflecting saturation of the intrinsic-factor pathway
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Antimicrobial Agents Chemotherapy 1984;25:20-4
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