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The 48-week extension trial (TIPO-4) demonstrated sustained efficacy, with participants maintaining a total mean weight loss of 13-14kg over the extended treatment period, confirming long-term effectiveness without significant tolerance development
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[PubMed] [Google Scholar] Hernandez DE, Stanley DA, Melvin JA, Prange AJ Jr., Jr Role of brain neurotransmitters on neurotensin-induced gastric cytoprotection
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