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Ferroptosis causes damage to the membranes and neuronal death by redox imbalance via iron metabolism, glutathione (GSH) depletion, and lipid peroxidation (Wang et al., 2023)
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However, elevated intracellular iron levels promote the conversion of IRP1 to ACO1, reflecting a paradox between iron-induced ferroptosis and ACO1-mediated ferroptosis inhibition
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