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On the immune side, luteolin shifted macrophages from a pro-inflammatory M1 phenotype toward the reparative M2 state through an AMPK–PPARγ pathway, quercetin inhibited the cGAS–STING pathway in intestinal macrophages, and chlorogenic acid restored the Th1/Th2 lymphocyte balance while making dendritic cells more tolerogenic
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Ultimately, this progression may culminate in right ventricular hypertrophy (RVH), fibrosis (Figure 1), heart failure in severe instances, and mortality [2, 14, 15]
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