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Instead, approved interventions are stratified according to a patient's body mass index (BMI), the presence of weight-related health conditions, and their individual clinical circumstances
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Dihexa’s trajectory—from claims of being “seven orders of magnitude more potent than BDNF” in rodents to a failed Phase 2/3 trial and retracted foundational research—exemplifies this “valley of death.” This pattern demands particular caution when extrapolating from compelling animal data to expectations for human cognitive benefit
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