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Autophagy was shown to mitigate AKI in a mouse model of IRI indicating that autophagy protects proximal tubular epithelial cells and that tubular epithelial cell injury was worsened by targeted suppression of the Atg5 gene[110]
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3.2 Synaptic plasticity After an ischemic stroke, there is a reduction in dendritic spine density in the peri-infarct area (Mostany et al., 2010), followed by restoration of spines over time ( Astrocytes detect and respond to neuronal activity, influencing the formation of synapses during development and adulthood (Kucukdereli et al., 2011
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