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The site 1 binding surface of insulin is comprised of residues GlyA1, GlnA5, TyrA19, AsnA21, ValB12, TyrB16, PheB24, PheB25, and TyrB26 ( Figure 1E ), while the site 2 surface is composed of residues SerA12, LeuA13, GluA17, HisB10, GluB13, and LeuB17 ( Figure 1F ) (39, 40)
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