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Excessively high plasma concentrations of Hcy, known as HHcy, lead to platelet activation and aggregation, hypercoagulability (activation of clotting factors V and VII), oxidative stress, vascular endothelial dysfunction, and the formation of atherosclerotic lesions
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Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients
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