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Early effective interventions may spare such individuals the morbidity of painful stone episodes and potential long-term complications, such as kidney failure [55]
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During ferroptosis, GPX4 binds to GSH to reduce lipid peroxides (such as PE-PUFA-OOH) to their corresponding alcohols, preventing lipid peroxide accumulation and protecting cellular membranes and structures from oxidative damage (20, 26)
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