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GH is the main inducer of ALS synthesis (Ooi et al., 1997) and in the circulation ALS can be found free or bound to IGF-I or -2 and IGFBP-3 or -5, to form a ternary complex (Baxter, 1994), which prevents IGFs, free or bound to IGFBPs, from leaving the circulation, thus prolonging their half-lives and decreasing their availability at a tissue level
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