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Echinochrome A, a natural bioproduct extracted from sea urchin, protects mitochondrial function against oxidative stress damage by activating AMPK phosphorylation and regulating the AMPKα/Nrf2/HO-1 pathway [147]
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In terms of potential antitumor activity, γ-glutamyl-protected N -hydroxyguanidines (NHGs) have been developed to explore the ability to deliver NO to the kidney ( Figure 5A )
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