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Consider testing for MTHFR gene mutations if you experience: Recurrent pregnancy loss — two or more miscarriages Infertility or difficulty conceiving — unexplained reproductive challenges Family history of cardiovascular disease — especially stroke, heart attack, or blood clots at young ages Elevated homocysteine levels — discovered through routine blood work Treatment-resistant mental health issues — anxiety or depression that doesn’t respond to standard medications Multiple unexplained symptoms — chronic fatigue, brain fog, hormonal imbalances, digestive issues Personal or family history of blood clots — DVT, pulmonary embolism, or clotting disorders Planning pregnancy — especially if you have risk factors for neural tube defects MTHFR testing is a simple blood or saliva test available through your doctor or direct-to-consumer genetic testing services

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It is now permitted up to the manufacturer’s maximum recommended inhaled dose of 1 puff (25 mcg) per day