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glutathione depletion and oxidative stress Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ch
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The most common mutations are Chromosome 9 open reading frame 72 ( C9orf72 ), copper–zinc Superoxide dismutase ( SOD1 ), trans-activation response DNA-binding protein 43 ( TARDPB ) and fused in sarcoma/translated in liposarcoma ( FUS/TLS )
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• Measured Binding Affinity: Potentiometric analysis yields a conditional Cu(II) binding constant of log K₁ = 12.62 for the GHK-copper complex at physiological pH — high enough to strip copper from weaker physiological ligands (PMID 32867146)
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